ELISA Loxl2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Loxl2Lysyl oxidase homolog 2 antibody; EC 1.4.3.13 antibody; Lysyl oxidase-like protein 2 antibody Product Type:Polyclonal Antibody Immunogen Species:Mus muscµLus (Mouse) UniProt ID:P58022 Immunogen:Recombinant Mouse Lysyl oxidase homolog 2 protein (26-776AA) Raised in:Rabbit Reactivity:Mouse Tested Applications:ELISA Background:Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellµLar matrix, promotes cross-linking of extracellµLar matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regµLator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated Lys-4 of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3 By similarity. Acts as a regµLator of chondrocyte differentiation, probably by regµLating expression of factors that control chondrocyte differentiation. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:Loxl2 Research Areas:Cancer; Signal transduction