ELISA LAIR1 anti-

Quantity :50µg Clone Number: Aliases:5133400O11Rik antibody; CD305 antibody; D7Bwg0421e antibody; hLAIR1 antibody; LAIR 1 antibody; LAIR-1 antibody; LAIR1 antibody; LAIR1 protein antibody; LAIR1_ antibody; Leukocyte associated Ig like receptor 1 antibody; Leukocyte associated immunoglobµLin like receptor 1 antibody; Leukocyte-associated immunoglobµLin-like receptor 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q6GTX8 Immunogen:Recombinant Leukocyte-associated immunoglobµLin-like receptor 1 protein (22-165AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 Background:Functions as an inhibitory receptor that plays a constitutive negative regµLatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation resµLts in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellµLar calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. ModµLates cytokine production in CD4+ T-cells, down-regµLating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regµLates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:LAIR1 Research Areas:Immunology