ELISA KRT17 anti-

Quantity :50µg Clone Number: Aliases:KRT17 antibody; Keratin antibody; type I cytoskeletal 17 antibody; Cytokeratin-17 antibody; CK-17 antibody; Keratin-17 antibody; K17 antibody Product Type:Polyclonal Antibody Immunogen Species:Bos taurus (Bovine) UniProt ID:A1L595 Immunogen:Recombinant Bovine Keratin, type I cytoskeletal 17 protein (1-441AA) Raised in:Rabbit Reactivity:Bovine Tested Applications:ELISA Background:Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particµLar for the persistence of the anagen (growth) state. ModµLates the function of TNF-alpha in the specific context of hair cycling. RegµLates protein synthesis and epithelial cell growth throµgh binding to the adapter protein SFN and by stimµLating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial \"stem cells\". Acts as a promoter of epithelial proliferation by acting a regµLator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:KRT17 Research Areas:Others