ELISA KPNA4 Antibody, HRP

Quantity :50µg Clone Number: Aliases:FLJ31113 antibody; IMA3_ antibody; Importin alpha 3 antibody; Importin alpha 4 subunit antibody; Importin alpha Q1 antibody; Importin subunit alpha 3 antibody; Importin subunit alpha-3 antibody; IPO A3 antibody; IPOA 3 antibody; IPOA3 antibody; Karyopherin alpha 4 (importin alpha 3) antibody; Karyopherin alpha 4 antibody; Karyopherin alpha 4 importin alpha 3 antibody; Karyopherin alpha 4 subunit antibody; Karyopherin subunit alpha 4 antibody; Karyopherin subunit alpha-4 antibody; KPNA 4 antibody; Kpna4 antibody; MGC12217 antibody; MGC26703 antibody; OTTHUMP00000213880 antibody; QIP 1 antibody; Qip1 antibody; Qip1 protein antibody; SRP 3 antibody; SRP3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O00629 Immunogen:Recombinant Importin subunit alpha-3 protein (51-239AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 throµgh binding to nucleoporin FxFG repeats and the complex is subsequently translocated throµgh the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thoµght to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of cytomegalovirus µL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of cytomegalovirus µL84 by recognizing a non-classical NLS. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:KPNA4 Research Areas:Signal transduction