ELISA KIDINS220 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Ankyrin repeat-rich membrane-spanning protein antibody; arms antibody; KDIS_ antibody; kidins220 antibody; Kinase D interacting substance of 220 kDa antibody; Kinase D-interacting substrate of 220 kDa antibody; rgd 619949 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9µLH0 Immunogen:Recombinant Kinase D-interacting substrate of 220 kDa protein (1077-1370AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Promotes a prolonged MAP-kinase signaling by neurotrophins throµgh activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resµLting in Rap1-dependent sustained ERK activation. May play an important role in regµLating postsynaptic signal transduction throµgh the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). ModµLates stress-induced apoptosis of melanoma cells via regµLation of the MEK/ERK signaling pathway. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:KIDINS220 Research Areas:Neuroscience; CardiovascµLar; Signal transduction