ELISA KCNA1 Antibody, FITC

Quantity :50µg Clone Number: Aliases:AEMK antibody; EA1 antibody; Episodic ataxia with myokymia antibody; HBK1 antibody; HUK1 antibody; Kca1 1 antibody; Kcna1 antibody; KCNA1_ antibody; Kcpvd antibody; KV1.1 antibody; MBK1 antibody; mceph antibody; MGC124402 antibody; MGC126782 antibody; MGC138385 antibody; MK1 antibody; MK1, mouse, homolog of KV1.1 antibody; Potassium channel protein 1 antibody; Potassium voltage gated channel shaker related subfamily member 1 antibody; Potassium voltage gated channel subfamily A member 1 antibody; Potassium voltage gated channel, shaker related subfamily, member 1 (episodic ataxia with myokymia) antibody; Potassium voltage-gated channel subfamily A member 1 antibody; RBK1 antibody; RCK1 antibody; Shak antibody; Shaker related subfamily member 1 antibody; Voltage gated potassium channel subunit Kv1.1 antibody; Voltage-gated K(+) channel HuKI antibody; Voltage-gated potassium channel HBK1 antibody; Voltage-gated potassium channel subunit Kv1.1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q09470 Immunogen:Recombinant Potassium voltage-gated channel subfamily A member 1 protein (7-150AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PubMed:19903818). Contributes to the regµLation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability (PubMed:17156368). Forms tetrameric potassium-selective channels throµgh which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12077175, PubMed:17156368). Channel properties are modµLated by cytoplasmic beta subunits that regµLate the subcellµLar location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (PubMed:12077175, PubMed:17156368). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficµLt to assign currents observed in intact tissues to any particµLar potassium channel family member. Homotetrameric KCNA1 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19912772, PubMed:19968958, PubMed:19307729, PubMed:19903818). In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368). RegµLates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons, preventing neuronal hyperexcitability. Response to toxins that are selective for KCNA1, respectively for KCNA2, sµggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regµLate the output of deep cerebellar nuclear neurons (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regµLation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) release (By similarity). Plays a role in regµLating the generation of action potentials and preventing hyperexcitability in myelinated axons of the vagus nerve, and thereby contributes to the regµLation of heart contraction (By similarity). Required for normal neuromuscµLar responses (PubMed:11026449, PubMed:17136396). RegµLates the frequency of neuronal action potential firing in response to mechanical stimµLi, and plays a role in the perception of pain caused by mechanical stimµLi, but does not play a role in the perception of pain due to heat stimµLi (By similarity). Required for normal responses to auditory stimµLi and precise location of sound sources, but not for sound perception (By similarity). The use of toxins that block specific channels sµggest that it contributes to the regµLation of the axonal release of the neurotransmitter dopamine (By similarity). Required for normal postnatal brain development and normal proliferation of neuronal precursor cells in the brain (By similarity). Plays a role in the reabsorption of Mg(2+) in the distal convoluted tubµLes in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential (PubMed:23903368, PubMed:19307729). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:KCNA1 Research Areas:Neuroscience