ELISA ITGB3 anti-

Quantity :50µL Clone Number: Aliases:BDPLT16 antibody; BDPLT2 antibody; CD 61 antibody; CD61 antibody; CD61 antigen antibody; GP3A antibody; GPIIIa antibody; GT antibody; HPA 1 antibody; HPA 4 antibody; Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) antibody; Integrin beta chain beta 3 antibody; Integrin beta-3 antibody; ITB3_ antibody; ITG B3 antibody; ITGB 3 antibody; ITGB3 antibody; NAIT antibody; platelet fibrinogen receptor antibody; Platelet fibrinogen receptor beta subunit antibody; Platelet fibrinogen receptor, beta subunit antibody; Platelet glycoprotein IIIa antibody; Platelet glycoprotein IIIa precursor antibody; Platelet membrane glycoprotein IIIa antibody; PTP antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P05106 Immunogen:Recombinant Integrin beta-3 protein (609-788AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodµLin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction throµgh binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plµgs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellµLar viral Tat protein seems to enhance angiogenesis in Kaposi\\\'s sarcoma lesions. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ITGB3 Research Areas:CardiovascµLar; Immunology; Signal transduction