ELISA IRF7 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:IMD39 antibody; Interferon regµLatory factor 7 antibody; Interferon regµLatory factor 7H antibody; IRF 7 antibody; IRF 7A antibody; IRF 7H antibody; IRF-7 antibody; IRF7 antibody; IRF7_ antibody; IRF7A antibody; IRF7B antibody; IRF7C antibody; IRF7H antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q92985 Immunogen:Recombinant Interferon regµLatory factor 7 protein (131-289AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Key transcriptional regµLator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. RegµLates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimµLated genes (ISG) by binding to an interferon-stimµLated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regµLating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or throµgh induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regµLation of EBV latency. Can activate distinct gene expression programs in macrophages and regµLate the anti-tumor properties of primary macrophages. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:IRF7 Research Areas:Epigenetics and Nuclear Signaling; Immunology; Microbiology