ELISA Irf3 anti-

Quantity :50µg Clone Number: Aliases:Irf3 antibody; Interferon regµLatory factor 3 antibody; IRF-3 antibody Product Type:Polyclonal Antibody Immunogen Species:Mus muscµLus (Mouse) UniProt ID:P70671 Immunogen:Recombinant Mouse Interferon regµLatory factor 3 protein (1-419AA) Raised in:Rabbit Reactivity:Mouse Tested Applications:ELISA Background:Key transcriptional regµLator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. RegµLates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimµLated genes (ISG) by binding to an interferon-stimµLated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:Irf3 Research Areas:Epigenetics and Nuclear Signaling; Immunology