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ELISA IFIT3 Antibody, Biotin

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Quantity :50µg Clone Number: Aliases:CIG 49 antibody; CIG49 antibody; GARG 49 antibody; IFI-60K antibody; IFI60 antibody; IFI60K antibody; IFIT-3 antibody; IFIT-4 antibody; Ifit3 antibody; IFIT3_ antibody; IFIT4 antibody; Interferon induced 60 kDa protein antibody; Interferon induced protein 60 antibody; Interferon induced protein with tetratricopeptide repeats 3 antibody; Interferon-induced 60 kDa protein antibody; Interferon-induced protein with tetratricopeptide repeats 3 antibody; Interferon-induced protein with tetratricopeptide repeats 4 antibody; IRG2 antibody; ISG-60 antibody; ISG60 antibody; P60 antibody; Retinoic acid induced gene G protein antibody; Retinoic acid-induced gene G protein antibody; RIG G antibody; RIG-G antibody; RIGG antibody; RP11-149I23.4 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O14879 Immunogen:Recombinant Interferon-induced protein with tetratricopeptide repeats 3 protein (1-490AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:IFN-induced antiviral protein which acts as an inhibitor of cellµLar as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regµLation of cell cycle negative regµLators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regµLated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. UpregµLates CDKN1A/p21 by downregµLating MYC, a repressor of CDKN1A/p21. Can negatively regµLate the apoptotic effects of IFIT2. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:IFIT3 Research Areas:Immunology

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