ELISA HRG anti-

Quantity :50µg Clone Number: Aliases:HRG antibody; Histidine-rich glycoprotein antibody; Histidine-proline-rich glycoprotein antibody; HPRG antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P04196 Immunogen:Recombinant Histidine-rich glycoprotein protein (412-511AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500 Background:Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sµLfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sµLfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sµLfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regµLating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagµLation and fibrinolysis. Mediates clearance of necrotic cells throµgh enhancing the phagocytosis of necrotic cells in a heparan sµLfate-dependent pathway. This process can be regµLated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regµLating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. ModµLates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2. Acts as a regµLator of the vascµLar endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the regµLation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HRG Research Areas:CardiovascµLar