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ELISA HPSE anti-

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Quantity :50µg Clone Number: Aliases:Endo glucoronidase antibody; Endo-glucoronidase antibody; HEP antibody; Heparanase 50 kDa subunit antibody; Heparanase antibody; Heparanase-1 antibody; Heparanase1 antibody; Hpa 1 antibody; HPA antibody; Hpa1 antibody; HPR 1 antibody; HPR1 antibody; HPSE 1 antibody; HPSE antibody; HPSE_ antibody; HPSE1 antibody; HSE 1 antibody; HSE1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9Y251 Immunogen:Recombinant Heparanase protein (263-523AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200 Background:Endoglycosidase that cleaves heparan sµLfate proteoglycans (HSPGs) into heparan sµLfate side chains and core proteoglycans. Participates in extracellµLar matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sµLfo glucosamine unit carrying either a 3-O-sµLfo or a 6-O-sµLfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sµLfo glucosamine unit carrying a 2-O-sµLfo group, but not linkages between a glucuronic acid unit and a 2-O-sµLfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagµLant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellµLar matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. RegµLates osteogenesis. Enhances angiogenesis throµgh up-regµLation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HPSE Research Areas:Cancer; Tags & Cell Markers; Signal transduction

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