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ELISA Hmgb1 anti-

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Quantity :50µL Clone Number: Aliases:High mobility group protein B1 (Amphoterin) (Heparin-binding protein p30) (High mobility group protein 1) (HMG-1), Hmgb1, Hmg-1 Hmg1 Product Type:Polyclonal Antibody Immunogen Species:Rattus norvegicus (Rat) UniProt ID:P63159 Immunogen:Recombinant Rat High mobility group protein B1 protein (2-18aa) Raised in:Rabbit Reactivity:Rat Tested Applications:ELISA, WB; Recommended dilution: WB:1:1000-1:5000 Background:MµLtifunctional redox sensitive protein with various roles in different cellµLar compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecµLar pattern (DAMP) molecµLe that amplifies immune responses during tissue injury. Released to the extracellµLar environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells throµgh engagement of mµLtiple surface receptors. In the extracellµLar compartment fµLly reduced HMGB1 (released by necrosis) acts as a chemokine, disµLfide HMGB1 (actively secreted) as a cytokine, and sµLfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide (PubMed:11154118). Bound to RAGE mediates signaling for neuronal outgrowth (PubMed:1885601, PubMed:2461949, PubMed:7592757, PubMed:12183440). May play a role in accumµLation of expanded polyglutamine (polyQ) proteins. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:Hmgb1 Research Areas:Others

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