ELISA HCK anti-

Quantity :50µL Clone Number: Aliases:Bmk antibody; Hck 1 antibody; Hck antibody; HCK_ antibody; Hemopoietic cell kinase antibody; JTK9 antibody; p59-HCK/p60-HCK antibody; p59Hck antibody; p59HCK/p60HCK antibody; p61Hck antibody; Tyrosine protein kinase HCK antibody; Tyrosine-protein kinase HCK antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P08631 Immunogen:Recombinant Tyrosine-protein kinase HCK protein (1-220AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regµLation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobµLins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranµLation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecµLes. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobµLin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HCK Research Areas:Immunology; Signal transduction