ELISA ARID1A anti-

Quantity :50µg Clone Number: Aliases:actin-dependent regµLator of chromatin subfamily F member 1 antibody; ARI1A_ antibody; ARID domain containing protein 1A antibody; ARID domain-containing protein 1A antibody; ARID1A antibody; AT rich interactive domain 1A (SWI like) antibody; AT rich interactive domain 1A antibody; AT rich interactive domain containing protein 1A antibody; AT-rich interactive domain-containing protein 1A antibody; B120 antibody; BAF250 antibody; BAF250A antibody; BM029 antibody; brain protein 120 antibody; BRG1 associated factor 250 antibody; BRG1 associated factor 250a antibody; BRG1-associated factor 250 antibody; BRG1-associated factor 250a antibody; C1ORF4 antibody; chromatin remodeling factor p250 antibody; chromosome 1 open reading frame 4 antibody; ELD antibody; hELD antibody; hOSA1 antibody; matrix-associated antibody; MRD14 antibody; Osa homolog 1 antibody; OSA1 antibody; OSA1 nuclear protein antibody; P270 antibody; SMARCF1 antibody; SWI like protein antibody; SWI SNF complex protein p270 antibody; SWI-like protein antibody; SWI/SNF complex protein p270 antibody; SWI/SNF related, matrix associated, actin dependent regµLator of chromatin, subfamily f, member 1 antibody; SWI/SNF-related antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O14497 Immunogen:Recombinant AT-rich interactive domain-containing protein 1A protein (655-816AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:500-1:1000 Background:Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adµLt state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the mµLtipotent neural stem cells. The nBAF complex along with CREST plays a role regµLating the activity of genes essential for dendrite growth (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ARID1A Research Areas:Epigenetics and Nuclear Signaling; Cancer; Signal transduction