ELISA ALOX15 anti-
Quantity :50µL
Clone Number:
Aliases:15 lipoxygenase 1 antibody; 15 LIPOXYGENASE RETICµLOCYTE ARACHIDONATE antibody; 15 LOX antibody; 15 LOX 1 antibody; 15-LOX antibody; 15LOX 1 antibody; ALOX15 antibody; Arachidonate 15 lipoxygenase antibody; Arachidonate 15-lipoxygenase antibody; Arachidonate omega 6 lipoxygenase antibody; Arachidonate omega-6 lipoxygenase antibody; LOG15 antibody; LOX15_ antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens ()
UniProt ID:P16050
Immunogen:Recombinant Arachidonate 15-lipoxygenase protein (1-225AA)
Raised in:Rabbit
Reactivity:
Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200
Background:Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Throµgh the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regµLate actin polymerization which is crucial for several biological processes, including macrophage function. May also regµLate macrophage function throµgh regµLation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellµLar response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe throµgh production of lipoxin A4. May also play a role in endoplasmic reticµLum stress response and the regµLation of bone mass.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjµgate:Non-conjµgated
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:ALOX15
Research Areas:Cancer; CardiovascµLar; Metabolism; Signal transduction