ELISA AIM2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Absent in melanoma 2 antibody; AIM 2 antibody; Aim2 antibody; AIM2_ antibody; Interferon-inducible protein AIM2 antibody; OTTHUMP00000035296 antibody; PYHIN4 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O14862 Immunogen:Recombinant Interferon-inducible protein AIM2 protein (81-326AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thoµght to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:AIM2 Research Areas:Epigenetics and Nuclear Signaling; Cancer