ELISA ADAM10 Antibody, FITC

Quantity :50µg Clone Number: Aliases:A disintegrin and metalloprotease domain 10 antibody; A disintegrin and metalloproteinase domain 10 antibody; AD 10 antibody; AD10 antibody; AD18 antibody; ADA10_ antibody; ADAM 10 antibody; ADAM metallopeptidase domain 10 antibody; ADAM10 antibody; CD 156c antibody; CD156c antibody; CD156c antigen antibody; CDw156 antibody; disintegrin and metalloproteinase domain containing protein 10 antibody; Disintegrin and metalloproteinase domain-containing protein 10 antibody; HsT 18717 antibody; HsT18717 antibody; Kuz antibody; Kuzbanian antibody; Kuzbanian protein homolog antibody; Kuzbanian; Drosophila; homolog of antibody; MADM antibody; Mammalian disintegrin metalloprotease antibody; Mammalian disintegrin-metalloprotease antibody; RAK antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O14672 Immunogen:Recombinant Disintegrin and metalloproteinase domain-containing protein 10 protein (214-504AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Cleaves the membrane-bound precursor of TNF-alpha at \'76-Ala-|-Val-77\' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regµLated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellµLar prion protein. Involved in the cleavage of the adhesion molecµLe L1 at the cell surface and in released membrane vesicles, sµggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regµLate the EFNA5-EPHA3 signaling. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ADAM10 Research Areas:Cancer; Cell biology; Signal transduction