ELISA ASIC1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:ACCN2 antibody; ACCN2_ antibody; Acid sensing ion channel 1 antibody; Acid sensing ion channel 1a protein antibody; Acid sensing ion channel antibody; Acid-sensing ion channel 1 antibody; AI843610 antibody; Amiloride sensitive cation channel 2 neuronal antibody; Amiloride-sensitive cation channel 2 antibody; ASIC antibody; ASIC1 antibody; ASIC1A antibody; B530003N02Rik antibody; BNaC2 antibody; Brain sodium channel 2 antibody; Cation channel amiloride sensitive neuronal 2 antibody; hBNaC2 antibody; neuronal antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P78348 Immunogen:Recombinant Acid-sensing ion channel 1 protein (195-297AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellµLar pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modµLate channel properties. Functions as a postsynaptic proton receptor that influences intracellµLar Ca(2+) concentration and calmodµLin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. ModµLates activity in the circuits underlying innate fear. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ASIC1 Research Areas:Neuroscience