ELISA GRB2 Monoclonal anti-

Quantity :100µL Clone Number: Aliases:Abundant SRC homology; Adapter protein GRB2; ASH; Ash protein; EGFRBP GRB2; Epidermal growth factor receptor binding protein; Epidermal growth factor receptor binding protein GRB2; GRB 2; GRB2 adapter protein; Grb2; GRB2_; Grb3 3; Product Type:Monoclonal Antibody Immunogen Species: UniProt ID:P62993 Immunogen:Purified recombinant GRB2 protein fragments expressed in E.coli. Raised in:Mouse Reactivity:,Rat,Mouse,Monkey Tested Applications:ELISA,WB;Recommended dilution:WB:1:500-1:5000 Background:Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. Clonality:Monoclonal Isotype:IgG1 Purification Method:Affinity purified Conjµgate:Non-conjµgated Buffer:Ascites Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:GRB2 Research Areas:Cancer;Signal transduction