7-Chlorokynurenic acid (Standard) [18000-24-3]

7-Chlorokynurenic acid (Standard) [18000-24-3] : Size : 1L - Certification : Research Use Only - 7-Chlorokynurenic acid (Standard) is the analytical standard of 7-Chlorokynurenic acid. This product is intended for research and analytical applications. 7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 microM). 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 microM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery[1][2]. -