ELISA ASIP Antibody, Biotin

Quantity :50µg Clone Number: Aliases:ASIP antibody; AGTI antibody; AGTIL antibody; ASP antibody; Agouti-signaling protein antibody; ASP antibody; Agouti switch protein antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P42127 Immunogen:Recombinant Agouti-signaling protein (23-112AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Involved in the regµLation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regµLation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. CoµLd well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regµLating the lipid metabolism with adipocytes. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ASIP Research Areas:Neuroscience; Signal transduction